histopathology diagnosis of coeliac disease – clinicopathological correlation is key!

Histopathology diagnosis of coeliac disease – clinicopathological correlation is key!

A robust diagnosis of coeliac disease is paramount for patient and clinician. The recent paper and subsequent editorial in this journal emphasises this point (1,2). However there is little mention of recent evidence based international guidelines in considering which classifications to use (3-5). These guidelines are carefully considered by the authors, have undergone rigorous review and are ba...

Coeliac disease diagnosis: has histopathology become redundant?

[Meningococcal disease: clinicopathological correlation].

INTRODUCTION Clinicopathological correlation studies of cases admitted as meningococcal disease are scarce, although they can serve to elucidate clinically obscure cases. METHODS A descriptive approach was used to analyze 42 necropsies following clinical diagnosis of meningococcal disease, verifying the agreement between histopathological and clinical findings evaluated according to three cli...

COELIAC DISEASE Refractory coeliac sprue is a diffuse gastrointestinal disease

Background: Refractory coeliac sprue (RCS) with an immunophenotypically aberrant clonal intraepithelial lymphocyte (IEL) population is considered a cryptic form of intestinal T cell lymphoma. Aims: To investigate the distribution of the abnormal and monoclonal IEL population in the digestive tract of RCS patients. Patients and methods: We compared the frequency of lymphocytic gastritis (LG) and...

Coeliac disease. Reappraisal of clinical diagnosis.

Cook, D. M., Evans, N., Lloyd, A., and Stewart, J. S. (1971). Archives of Disease in Childhood, 46, 705. Coeliac disease: reappraisal of clinical diagnosis. Twelve children previously diagnosed as having coeliac disease on criteria now regarded as incomplete have been reinvestigated. Six were found to have an intestinal mucosal lesion characteristic of coeliac disease. All but one had been asym...

Diagnosis of coeliac disease in retrospect.

There are today a number of children who were originally diagnosed as having coeliac disease by criteria that we should now regard as inadequate. Almost all of these are receiving a gluten-free diet. It is clearly of importance to substantiate the diagnosis, since current concepts of coeliac disease demand strict and prolonged dietary control, lasting at least until after the pubertal growth sp...